What To Expect When Starting CONTRAVE

CONTRAVE is a unique combination of two drugs—naltrexone and bupropion—within a single extended-release tablet clinically proven to help you lose weight and keep it off when combined with diet and exercise.

CONTRAVE is Clinically Proven to Help You Lose Weight

Across 3 studies, patients who were overweight or suffering from obesity lost approximately 2-4x more weight over 1 year by adding CONTRAVE than with diet and exercise alone.*

Nearly half of the patients taking CONTRAVE lost 5% or more body weight and kept it off (vs 23% of patients taking placebo).*

Nearly half of the patients taking CONTRAVE lost 5% or more body weight and kept it off (vs 23% of patients taking placebo).*

One of the most important things to know when starting CONTRAVE (or any weight loss program) is that success looks different for each person. How fast this success happens for you and how many inches you lose or pounds you drop will depend on your body. In clinical studies, the most dramatic weight loss was typically seen after 4 months (16 weeks) of taking CONTRAVE as prescribed.

*According to 3 multicenter, double-blind, placebo-controlled obesity trials (BMI 2:30 kg/m2 , or BMI 2:27 kg/m2 with at least 1 comorbidity of hypertension, dyslipidemia, or type 2 diabetes) conducted to evaluate the effect of CONTRAVE in conjunction with reduced caloric intake and increased physical activity, the average percentage of weight loss in patients at 56 weeks ranged from 3.7% to 8.1% with CONTRAVE, compared to 1.3% to 4.9% with placebo. The percentage of patients who achieved a clinically meaningful treatment response (defined as achieving at least 5% weight loss after 1 year of treatment) ranged from 36% to 57% with CONTRAVE, compared to 17% to 43% with placebo.

Managing Potential Side Effects

CONTRAVE safety was evaluated in thousands of patients.

Here are some things you can try if you are experiencing the following side effects.

What else to know:

If you’re experiencing any unwanted side effects of your medication, don’t hesitate to reach out to your healthcare provider or pharmacist—they can give you personalized guidance.


You are also encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088.


For best results, take CONTRAVE as directed by your healthcare provider. Most patients begin with 1 morning pill during the first week and gradually work their way up to 2 pills twice a day by week 4. Always take CONTRAVE exactly as prescribed by your doctor. Your doctor may change your dose as needed.

Drink Plenty of Water When Taking CONTRAVE
Swallow CONTRAVE Pills Whole

Resources to Support You from the Start

We know that being successful in achieving your weight-loss goals takes planning and time – that’s why we want to make sure you have all the resources you need to start your journey.




Get Real Advice From Real Patients!

Alisha: “Think of your weight loss and exercise program as a form of self-care.”

Janet: “Not only are you capable of positive change, but you also deserve it.”

Tori: “Learn to become friends with food—not enemies.”

Kalan: “Don’t restrict foods from yourself but pay attention to when you’re full.”