CONTRAVE is an FDA-approved oral weight-loss medication for people who are overweight or living with obesity. It’s designed to help reduce hunger and control cravings, like those associated with dealing with emotions like stress, so you can lose weight and keep it off.* Ready to start your journey?
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*The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood.
Along with diet and exercise, CONTRAVE, a weight-loss pill, is for adults with a body mass index (BMI) ≥30 or with a BMI ≥27 who have a weight-related medical problem.
When it comes to creating a weight-loss plan, one size doesn't fit all. Everyone faces different challenges that can keep them from weight-loss success. For some, controlling cravings when dealing with emotions like stress or boredom can be difficult. If this sounds familiar, adding CONTRAVE to diet and exercise may help you lose weight and keep it off.*
When I started taking CONTRAVE, I began to feel control over my cravings for the first time.
– Janet
Real quote from a patient taking CONTRAVE at the time of their interview. Individual results may vary. CONTRAVE is intended to be used along with a reduced-calorie diet and increased physical activity.
Real quote from a patient taking CONTRAVE at the time of their interview. Individual results may vary. CONTRAVE is intended to be used along with a reduced-calorie diet and increased physical activity.
Explore some common questions to help you decide if CONTRAVE can support your weight-loss journey.
Many weight-loss pills and supplements are out there, but not all work the same. If you’re thinking about adding a weight-loss pill to support your weight-loss efforts, consider asking your healthcare provider about a weight-loss medication that’s FDA approved. Prescription weight-loss pills like CONTRAVE can help people get closer to their weight-loss goals when used with diet and exercise. Find out if CONTRAVE could be right for you.
Some weight-loss pills reduce fat absorption, while other weight-loss pills, like CONTRAVE, can help control hunger and cravings. If you’re struggling to lose weight and find it hard to manage hunger and cravings, CONTRAVE may help. Learn more about how CONTRAVE works.
CONTRAVE is a prescription medication designed to aid weight loss in adults with obesity (BMI ≥30) or those who are overweight (BMI ≥27) with at least 1 weight-related health condition. CONTRAVE should be combined with diet and regular exercise to be effective.
While the precise neurochemical mechanisms of CONTRAVE are not entirely known, it is thought to work with 2 parts of the brain*:
These effects can support weight-loss efforts.
*Other areas of the brain may be involved. The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood.
Have more questions about CONTRAVE? See FAQs.
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Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment.
While taking CONTRAVE, you or your family members should pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when you start taking CONTRAVE or when your dose changes.
Stop taking CONTRAVE and call a healthcare provider right away if you or your family members notice any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempts to commit suicide; depression; anxiety; feeling agitated or restless; panic attacks; irritability; aggression, anger, or violence; acting on dangerous impulses; an extreme increase in activity and talking; other unusual changes in behavior or mood; trouble sleeping.
CONTRAVE is not approved for use in children under the age of 18.
Do not take CONTRAVE if you have uncontrolled high blood pressure; have or have had seizures; use other medicines that contain bupropion such as WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, APLENZIN and ZYBAN; have or have had an eating disorder called anorexia or bulimia; are dependent on opioid pain medicines or use medicines to help stop taking opioids, or are in opiate withdrawal; drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy), benzodiazepines, or anti‐seizure medicines and stop using them all of a sudden; are taking or have taken medicines called monoamine oxidase inhibitors (MAOIs) in the past 14 days; or are allergic to any of the ingredients in CONTRAVE.
Tell your healthcare provider about all of your medical conditions, including if you have: depression or other mental illnesses; attempted suicide; seizures; head injury; tumor or infection of brain or spine; low blood sugar or low sodium; liver or kidney problems; high blood pressure; heart attack, heart problems, or stroke; eating disorder; drinking a lot of alcohol; prescription medicine or street drug abuse; are 65 or older; diabetes; pregnant or planning to become pregnant; or breastfeeding.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Seizures. There is a risk of having a seizure when you take CONTRAVE. The risk of seizure is higher in people who take higher doses of CONTRAVE, have certain medical conditions, or take CONTRAVE with certain other medicines. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider has said it is okay to take them. If you have a seizure while taking CONTRAVE, stop taking CONTRAVE and call your healthcare provider right away.
Risk of opioid overdose. Do not take large amounts of opioids, including opioid-containing medicines, such as heroin or prescription pain pills, to try to overcome the opioid-blocking effects of naltrexone. This can lead to serious injury, coma, or death.
Get emergency medical help right away if you take opioids and you:
have trouble breathing
become very drowsy with slowed breathing
have slow, shallow breathing
feel faint, very dizzy, confused, or have unusual symptoms
Sudden opioid withdrawal. People who take CONTRAVE must not use any type of opioid, including street drugs, prescription pain medicines, cough, cold, or diarrhea medicines that contain opioids, or opioid dependence treatments, for at least 7 to 10 days before starting CONTRAVE. Using opioids in the 7 to 10 days before you start taking CONTRAVE may cause you to suddenly have symptoms of opioid withdrawal when you take it. Sudden opioid withdrawal can be severe, and you may need to go to the hospital. Tell your healthcare provider you are taking CONTRAVE before a medical procedure or surgery.
Severe allergic reactions. Stop taking CONTRAVE and call your healthcare provider or go to the nearest hospital emergency room right away if you have any of the following signs and symptoms of an allergic reaction: rash, itching, hives, fever, swollen lymph glands, painful sores in your mouth or around your eyes, swelling of your lips or tongue, chest pain, or trouble breathing.
Increases in blood pressure or heart rate. Some people may get high blood pressure or have a higher heart rate when taking CONTRAVE. Your healthcare provider should check your blood pressure and heart rate before you start taking, and while you take CONTRAVE.
Liver damage or hepatitis. Stop taking CONTRAVE and tell your healthcare provider if you have any of the following symptoms of liver problems: stomach area pain lasting more than a few days, dark urine, yellowing of the whites of your eyes, or tiredness. Your healthcare provider may need to stop treating you with CONTRAVE if you get signs or symptoms of a serious liver problem.
Manic episodes. Bupropion can cause some people who were manic or depressed in the past to become manic or depressed again.
Visual problems (angle-closure glaucoma). Signs and symptoms may include: eye pain, changes in vision, swelling or redness in or around the eye. Talk with your healthcare provider to find out if you are at risk for angle‐closure glaucoma and to get treatment to prevent it if you are at risk.
Increased risk of low blood sugar in people with type 2 diabetes mellitus who also take medicines to treat their diabetes (such as insulin or sulfonylureas). You should check your blood sugar before you start taking CONTRAVE and while you take CONTRAVE.
The most common side effects of CONTRAVE include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea. These are not all of the possible side effects of CONTRAVE.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
CONTRAVE is a prescription weight-loss medicine that may help some adults with a body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes, lose weight and keep the weight off.
CONTRAVE should be used with a reduced-calorie diet and increased physical activity.
It is not known if CONTRAVE changes your risk of heart problems or stroke or of death due to heart problems or stroke.
It is not known if CONTRAVE is safe and effective when taken with other prescription, over-the-counter, or herbal weight-loss products.
CONTRAVE is not approved to treat depression or other mental illnesses, or to help people quit smoking (smoking cessation).
Please see Full Prescribing Information, including Medication Guide, for CONTRAVE.
