The Science Behind CONTRAVE

The Struggle to Lose Weight and Keep It Off Is Real

There is a real weight-loss struggle that happens to many of us—and it’s not due to lack of commitment or effort. Through science, we can better understand this challenge because it turns out your brain may be working against you by sending hunger signals or triggering cravings, even when you’re not hungry.

See how 2 areas in the brain can cause hunger and cravings*

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*Other areas of the brain may be involved.

See how CONTRAVE is thought to act on those same 2 areas of the brain

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The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood.

How CONTRAVE Can Help

Across 3 studies, patients who were overweight or struggling with obesity lost approximately 2-4x more weight over 1 year by adding CONTRAVE than with diet and exercise alone

Nearly half of patients taking CONTRAVE lost 5% or more body weight and kept it off (vs 23% of patients taking placebo). Individual results may vary.

According to 3 multicenter, double-blind, placebo-controlled obesity trials (BMI ≥30 kg/m2, or BMI ≥27 kg/m2 with at least 1 comorbidity of hypertension, dyslipidemia, or type 2 diabetes) conducted to evaluate the effect of CONTRAVE in conjunction with reduced caloric intake and increased physical activity, the average percentage of weight loss in patients at 56 weeks ranged from 3.7% to 8.1% with CONTRAVE, compared to 1.3% to 4.9% with placebo. The percentage of patients who achieved a clinically meaningful treatment response (defined as achieving at least 5% weight loss after 1 year of treatment) ranged from 36% to 57% with CONTRAVE compared to 17% to 43% with placebo.

Start Your Journey

Select the best way for you to talk to a doctor about CONTRAVE.