**Based on the number of prescription fills for a brand name weight-loss drug in the IQVIA database June 2022 - May 2023
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Body mass index (BMI) is a measure of body fat based on height and weight. BMI is a simple screening method to help doctors determine if a patient is underweight, healthy weight, overweight, or obese. This measurement can be a first indicator if a patient is at risk for any weight-related health problems.
Hunger
happens when your brain tells you that it needs nutrition and that any food will satisfy this need.
Cravings
happen when your brain wants specific foods, even though you may not feel hungry.
†Other areas of the brain may be involved. The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood.
Through science, we can better understand this challenge because it turns out your brain may be working against you by sending hunger signals or triggering cravings, even when you're not hungry.
Real Life Results
"CONTRAVE helped me maintain control over cravings and portions. I've been able to keep the weight off!"
Melody
Real story from a patient taking CONTRAVE at the time of their interview. Individual results may vary. CONTRAVE is intended to be used along with a reduced-calorie diet and increased physical activity.
Through science, we can better understand this challenge because it turns out your brain may be working against you by sending hunger signals or triggering cravings, even when you're not hungry.
The hunger center (hypothalamus) can increase hunger, telling you to eat again or eat more
The mesolimbic circuit or reward system can create cravings that seem uncontrollable even when you’re not hungry
The efficacy and safety of CONTRAVE were assessed in the 56-week CONTRAVE Obesity Research (COR) clinical studies.
3
56-week
studies
2,322
patients
MORE INFORMATION
COLLAPSE
Some participants received CONTRAVE, and others were randomly selected to receive a placebo.
more weight lost
Across 3 different clinical studies, patients struggling with obesity who took CONTRAVE, along with diet and exercise, lost 2-4 times more weight over 1 year than with diet and exercise alone.
Along with diet and exercise, patients taking CONTRAVE lost more weight after 56 weeks of treatment than patients taking placebo.
The CONTRAVE group lost an average of 5.4% of their baseline body weight (or 12 pounds) compared with the placebo group, which lost an average of 1.3 % of their body weight (or 3 pounds).
In addition, 42% of CONTRAVE patients lost at least 5% of their total body weight (compared to 17% of placebo patients), and 21% of CONTRAVE patients lost at least 10% of their total body weight (compared with 7% of placebo patients).
Finally, the average waist reduction for patients taking CONTRAVE was 2.4 inches, compared to 1 inch for those in the placebo group.
The CONTRAVE group lost an average of 8.1% of their baseline body weight (or 18 pounds) compared with the placebo group, which lost an average of 4.9% of their body weight (or 11 pounds).
In addition, 57% of CONTRAVE patients lost at least 5% of their total body weight (compared with 43% of placebo patients), and 35% of CONTRAVE patients lost at least 10% of their total body weight (compared to 21% of those in the placebo group).
Finally, the average waist reduction for patients taking CONTRAVE was 3.9 inches, compared to 2.7 inches for those in the placebo group.
The CONTRAVE group lost an average of 3.7% of their baseline body weight (or 8.5 pounds) compared with the placebo group, which lost an average of 1.7% on average (or 4 pounds).
In addition, 36% of CONTRAVE patients lost at least 5% of their total body weight (compared with 18% of placebo patients), and 15% of CONTRAVE patients lost at least 10% of their total body weight (compared to 5% of those in the placebo group).
Finally, the average waist reduction for patients taking CONTRAVE was 2 inches, compared to 1.1 inches for those in the placebo group.
When added to diet and exercise, CONTRAVE is a long-term approach to help you achieve sustainable results. Your results may vary depending on your weight, body mass index (BMI), diet, activity level, and other factors.
Age: 59
Occupation: Museum Curator
Why CONTRAVE?
“I’ve struggled with managing my weight my entire life. My reactive eating behavior led to decades of huge weight gain.”
Age: 33
Occupation: Carpenter
Why CONTRAVE?
“When I was feeling stressed out, or just low, I found food to be extremely comforting. If I felt that someone was upset with me or treated me poorly, food became my comfort.”
Age: 35
Occupation: Events Manager
Why CONTRAVE?
“I’ve tried multiple diets and weight-loss programs with no success– from the beginning, I could feel a difference by adding CONTRAVE.”
Age: 29
Occupation: Stay-at-home mom
Why CONTRAVE?
“Growing up, I had always been a heavier-set person. I am six feet tall so it’s in my family genetics to be larger.”
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Next
Age: 59
Occupation: Museum Curator
Why CONTRAVE?
“I’ve struggled with managing my weight my entire life. My reactive eating behavior led to decades of huge weight gain.”
Age: 33
Occupation: Carpenter
Why CONTRAVE?
“When I was feeling stressed out, or just low, I found food to be extremely comforting. If I felt that someone was upset with me or treated me poorly, food became my comfort.”
Age: 35
Occupation: Events Manager
Why CONTRAVE?
“I’ve tried multiple diets and weight-loss programs with no success– from the beginning, I could feel a difference by adding CONTRAVE.”
Age: 29
Occupation: Stay-at-home mom
Why CONTRAVE?
“Growing up, I had always been a heavier-set person. I am six feet tall so it’s in my family genetics to be larger.”
All you need is 1 new day to make a change, and today is the day you're going to make it happen. Here's what to do next:
Prepare for your next
doctor visit
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conversation? Use this tool to gather
key information for your doctor to help them see if CONTRAVE is right for you. Start by answering a few questions about yourself.
Connect with a doctor
Looking for a doctor to talk to about CONTRAVE? Here’s how to get in touch with one:
CONTRAVE can cause serious side effects including:
Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment.
CONTRAVE is a prescription weight-loss medicine that may help some adults with a body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes, lose weight and keep the weight off.
CONTRAVE can cause serious side effects including:
Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment.
CONTRAVE is a prescription weight-loss medicine that may help some adults with a body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes, lose weight and keep the weight off.
CONTRAVE can cause serious side effects including:
Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment.
While taking CONTRAVE, you or your family members should pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when you start taking CONTRAVE or when your dose changes.
Stop taking CONTRAVE and call a healthcare provider right away if you or your family members notice any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempts to commit suicide; depression; anxiety; feeling agitated or restless; panic attacks; irritability; aggression, anger, or violence; acting on dangerous impulses; an extreme increase in activity and talking; other unusual changes in behavior or mood; trouble sleeping.
CONTRAVE is not approved for use in children under the age of 18.
Do not take CONTRAVE if you have uncontrolled high blood pressure; have or have had seizures; use other medicines that contain bupropion such as WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, APLENZIN and ZYBAN; have or have had an eating disorder called anorexia or bulimia; are dependent on opioid pain medicines or use medicines to help stop taking opioids, or are in opiate withdrawal; drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy), benzodiazepines, or anti‐seizure medicines and stop using them all of a sudden; are taking or have taken medicines called monoamine oxidase inhibitors (MAOIs) in the past 14 days; or are allergic to any of the ingredients in CONTRAVE.
Tell your healthcare provider about all of your medical conditions including if you have: depression or other mental illnesses; attempted suicide; seizures; head injury; tumor or infection of brain or spine; low blood sugar or low sodium; liver or kidney problems; high blood pressure; heart attack, heart problems, or stroke; eating disorder; drinking a lot of alcohol; prescription medicine or street drug abuse; are 65 or older; diabetes; pregnant or planning to become pregnant; or breastfeeding.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Get emergency medical help right away if you take opioids and you:
The most common side effects of CONTRAVE include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea. These are not all of the possible side effects of CONTRAVE.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
CONTRAVE is a prescription weight-loss medicine that may help some adults with a body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes, lose weight and keep the weight off.
CONTRAVE should be used with a reduced-calorie diet and increased physical activity.
It is not known if CONTRAVE changes your risk of heart problems or stroke or of death due to heart problems or stroke.
It is not known if CONTRAVE is safe and effective when taken with other prescription, over-the-counter, or herbal weight-loss products.
CONTRAVE is not approved to treat depression or other mental illnesses, or to help people quit smoking (smoking cessation).
Please see Full Prescribing Information, including Medication Guide, for CONTRAVE.
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Speak one-on-one with a licensed healthcare professional*
*If prescribed CONTRAVE, a $45 doctor consult fee is applied.
Pay no more than $99 for CONTRAVE and have it delivered to your home
If you have more questions, please visit our FAQs page.
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