When you’re trying to lose weight and keep it off, your brain could be working against you. Find out how CONTRAVE can help.

How Two Areas of the Brain Can Cause Hunger and Cravings*

*Other areas of the brain may be involved.

Understand Brain Role in Weight Loss With Contrave

Click here to read Important Safety Information

How CONTRAVE® Works*

*The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood.

Discover Benefits of a New Weight Loss Medication

Click here to read Important Safety Information

The Science Behind CONTRAVE®

CONTRAVE® is a prescription-only, FDA-approved weight-loss pill believed to work on two areas of your brain—the hunger center and the reward system—to reduce hunger and help control cravings.CONTRAVE contains two medicines, bupropion and naltrexone. These well-known drugs have been prescribed separately for years—bupropion for depression and smoking cessation, and naltrexone for alcohol and opioid dependence.2

1The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood.
2The individual components of CONTRAVE are not approved for weight loss. CONTRAVE is not approved to treat depression or other mental illnesses, alcohol or opioid dependency, or to help people quit smoking.

The mesolimbic reward system to help control cravings
The Science Behind Weight Loss Pills
The hypothalamus (hunger center) to reduce hunger

CONTRAVE has a well-studied safety and tolerability profile. Three long-term (56 weeks) studies have shown that patients who add CONTRAVE lose approximately 2 to 4 times more weight than with diet and exercise alone.3 In one study, patients who also participated in an intensive diet and exercise program and remained on CONTRAVE for a full year, lost 25 pounds on average.

3Across three 56-week studies, 46% of patients on CONTRAVE lost 5% or more body weight (vs 23% of patients on placebo). Results may vary.

Across three studies, patients who added CONTRAVE for a full year:

Lost Approximately

2-4x

more weight on average than with diet and exercise alone3

In one study, patients who took CONTRAVE for a full year and participated in intensive diet and exercise programs:

Lost

27lbs

on average

Did you know
that cravings are one of
the main reasons diets fail?

Learn More

Learn more about the potential for long-term weight loss with CONTRAVE

CONTRAVE was studied for efficacy and safety in
several clinical trials that included thousands of patients.

In three long-term studies,

2,322 participants

were enrolled who were struggling
with obesity (BMI of 30 or greater) or were overweight (BMI of 27 or greater).

Those with a BMI between 27 and 29.9 had at least one weight-related medical condition, such as controlled hypertension, dyslipidemia, or diabetes. While some participants received CONTRAVE, others were randomly selected to receive a placebo. Everyone participated in lifestyle modification programs that included a reduced-calorie diet and regular physical activity.

After 56 weeks, across the three studies,

46%

of patients taking CONTRAVE lost
5% or more
of their body weight with CONTRAVE

vs.
23%

of patients on placebo.

Study 1

In this 56-week study, patients taking CONTRAVE lost 5.4% of their body weight (on average) compared with the placebo group who lost 1.3% (on average) with diet and exercise alone.

Additionally, 42% of the CONTRAVE users lost at least 5% of their total body weight (while 17% of the placebo group lost at least 5% of their total body weight with diet and exercise).

For participants who remained on CONTRAVE for the whole study, average weight loss was 8.1% or approximately 18 pounds, which was 4 times more weight than participants taking placebo.

COR-1 study

Study 2

In this 56-week study, patients participated in an intensive diet and exercise program, including group visits. At 56 weeks, patients taking CONTRAVE lost 8.1% (on average) of their total body weight compared with a body weight loss of 4.9% (on average) for the placebo group.

Additionally, 57% of those who took CONTRAVE lost at least 5% of their total body weight (while 43% of those on placebo lost at least 5% body weight with diet and exercise alone).

For participants who remained on CONTRAVE for the whole study, average weight loss was 11.5% or approximately 25 pounds.

COR-BMOD study

Study 3

For people with type 2 diabetes, CONTRAVE has the potential to provide sustainable weight loss and this weight loss may also lower A1C levels. In this study, patients taking CONTRAVE lost 3.7% of their body weight (on average) compared with the placebo group who lost 1.7% (on average) with diet and exercise alone after 56 weeks.

Additionally, 36% of those who took CONTRAVE lost at least 5% of their total body weight (while 18% of the placebo group lost at least 5% of their total body weight with diet and exercise).

CONTRAVE users also had a reduction in HbA1c of 0.6% (compared with a reduction of 0.1% in the placebo group) at 56 weeks. (Keep in mind that CONTRAVE is not approved to treat diabetes.)

COR-Diabetes study

Taking CONTRAVE

If you’re new to CONTRAVE, it’s important to increase your dose slowly over time to help you adjust to the medication. Begin with one morning tablet during your first week, and then gradually work up to two tablets twice a day by week four. Remember to always take your CONTRAVE dose exactly as your doctor prescribes. Refer to this CONTRAVE dosing chart to help you stay on track, and know that some people, like those with renal or hepatic impairment, or those taking other medications, may need to follow a different dosing schedule.

Dosing for most patients taking CONTRAVE

How to Use Contrave for Weight Loss
Food Cravings Prevention Banner | Contrave.com

CONTRAVE may help patients make long-term changes to their eating behavior, lose weight, and keep it off. Across three long-term studies, patients taking CONTRAVE lost approximately 2-4x more weight than with diet and exercise alone. In one study, patients who stayed on CONTRAVE for a full year and participated in intensive behavior modification lost 25 pounds on average.

For people who started with a BMI 30 to 35, more than 70% of those who saw results at Week 16 and remained on treatment for 56 weeks were able to move into a healthier, non-obese category (BMI 29.9 or less) after 1 year on CONTRAVE*.

If you have not lost at least 5% of your body weight after 16 weeks of taking CONTRAVE, your healthcare provider might tell you to stop taking it. CONTRAVE does not work for everyone in the same way.

*Nalpropion data on file

CONTRAVE was studied for efficacy and safety in numerous clinical trials that included thousands of patients.

In general, it is recommended you drink plenty of water when taking CONTRAVE. Some people taking CONTRAVE experience nausea as they increase their dose. If you experience nausea, you may also want to eat a small amount of dry toast with CONTRAVE. For most people, this symptom went away within the first four weeks of taking CONTRAVE. If symptoms do not improve, please consult with your doctor who may also recommend an over-the-counter anti-nausea medication for you.

Other common side effects include constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea. Call your doctor if you experience side effects while taking CONTRAVE that bother you or don’t go away while taking CONTRAVE.

Be careful not to take CONTRAVE with high-fat meals, and also avoid drinking a lot of alcohol. Be sure to tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. This is important because CONTRAVE may affect the way other medications work, especially opioid medicines or medicines to help stop taking opioids.

Please see Full Prescribing Information or the Medication Guide for more details about CONTRAVE side effects and the complete Boxed Warning.

Talk to your doctor about ways to help control your cravings to lose weight.

Share the times and situations you find yourself struggling with cravings.
For example, do you…


1

Reward Cravings
Feel like you deserve to eat a special treat when something good happens?


2

Situational Cravings
Want to snack whenever you sit down to watch TV?


3

Emotional Cravings
Find yourself looking for comfort food when you’re stressed, lonely, or bored?

Take 2 minutes to fill out the
Doctor Discussion Guide
and review it with your doctor.

Start Here
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Weight Loss Success Stories With Contrave

Real Life Success Stories

"It seems like most things work at the beginning and dwindle off, but CONTRAVE is working long-term for me." - JoAnn
See Her Story