Get answers to your most frequently asked questions about CONTRAVE.

We want to answer your questions and support you on your weight-loss journey. Visit our Medication Guide for more information about CONTRAVE, or call one of our customer service representatives at 1-800-905-5576. You’ll also find answers to the most commonly asked questions below.


CONTRAVE is a prescription-only, FDA-approved weight-loss medication that may help adults who are overweight or struggle with obesity lose weight and keep it off. CONTRAVE should be used along with diet and exercise.

CONTRAVE contains two well-known FDA-approved drugs, naltrexone and bupropion that, individually, have been on the market for over 20 years. Naltrexone is an anti-addiction medication approved to treat alcohol and opioid dependence. Bupropion is an antidepressant approved to treat depression and seasonal affective disorder and is an aid to smoking cessation treatment. (These individual drugs are not approved for weight loss and CONTRAVE is not indicated for the treatment of depression, smoking cessation, or alcohol or opioid dependence.)

The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood.

CONTRAVE is believed to work on two areas of the brain—the hypothalamus to help reduce hunger and the mesolimbic reward system to help control cravings—that can get in the way of weight loss.

Across three one-year studies, nearly half of patients taking CONTRAVE lost 5% or more of their body weight versus 23% of patients on placebo.

CONTRAVE is approved for use in adults with a body mass index (BMI) of 30 or greater (obese) or 27 or greater (overweight) who have at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol. It is to be used along with a reduced-calorie diet and increased physical activity.

CONTRAVE is not for everyone. Do not take CONTRAVE if you:

  • Have a seizure disorder
  • Are pregnant or trying to get pregnant
  • Have an eating disorder such as anorexia or bulimia
  • Are under the age of 18
  • Have uncontrolled hypertension
  • Use other medicines that contain bupropion such as Wellbutrin and Aplenzin
  • Are dependent on opioid medicines or use medicines to help stop taking opioids, such as methadone or buprenorphine or are in opiate withdrawal
  • Drink a lot of alcohol and abruptly stop drinking
  • Use medicines called sedatives like benzodiazepines, or anti-seizure medicines, and you stop using them suddenly
  • Are allergic to any of the ingredients in CONTRAVE, such as naltrexone HCI and bupropion HCI
  • Are taking medicines called monoamine oxidase inhibitors (MAOIs)

See the Medication Guide to learn more.

CONTRAVE should be taken by mouth in the morning and in the evening and should not be taken with high-fat meals.

CONTRAVE dosing should be increased slowly according to the following schedule:

Dosing Chart


It’s important to take CONTRAVE exactly as your doctor prescribes it. Keep in mind that some people, like those with renal or hepatic impairment, or those taking other medications, may need to follow a different dosing schedule.A total daily dosage of two CONTRAVE tablets should be reached at the start of week four.

To learn more about dosing, see the Medication Guide.

The most common side effects reported with CONTRAVE include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.

If you experience any of the following, stop taking CONTRAVE and tell your healthcare provider right away:


  • Suicidal thoughts or actions
  • Seizures
  • Increases in blood pressure or heart rate
  • Liver damage or hepatitis (symptoms include stomach area pain lasting more than a few days, dark urine, yellowing of the whites of your eyes, or tiredness)
  • Manic episodes
  • Visual problems (symptoms include eye pain, changes in vision, swelling or redness in or around the eye)
  • Increased risk of low blood sugar (hypoglycemia) in people with type 2 diabetes mellitus who also take medicines to treat their diabetes (such as insulin or sulfonylureas)
  • Severe allergic reaction (signs and symptoms include rash, itching, hives, fever, swollen lymph glands, painful sores in your mouth or around your eyes, swelling of your lips or tongue, chest pain, or trouble breathing)

See the Full Prescribing Information or the Medication Guide to learn more about the possible side effects of CONTRAVE.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1‑800‑FDA‑1088.

About the CONTRAVE Savings Card

We no longer feature the login and account sections on the website. To help simplify your CONTRAVE experience, we now allow users to sign up for the Savings Card without a password.  If you have questions about your account, please reach out to our customer service representatives at 1-800-905-5576 and they will be happy to assist you.

Once you sign up for the CONTRAVE Savings Card, you will be able to upload it right away online. Print it or take a picture of it on your smartphone and bring it with you the first time you fill your prescription. Once you use your Savings Card at the pharmacy, you do not need to bring it again. The pharmacy will keep your card information on file.

If you’re paying cash, or if you have insurance that does not cover CONTRAVE, you may pay approximately $3 a day for your monthly prescription. If you have Medicare or TRICARE coverage, you may also pay approximately $3 a day for CONTRAVE.  If you have private health insurance that covers CONTRAVE, you may pay approximately $1 a day. Tell your pharmacist what kind of health insurance you have so you can pay the lowest copay possible.

You can register for the CONTRAVE Savings Card here. If you are having trouble signing up online, you can call 1-800-905-5576 for assistance.

The CONTRAVE Savings Card cannot be used if you are currently a Medicaid Beneficiary. Medicare Part D, and TRICARE beneficiaries are eligible for CONTRAVE Savings. However, to receive the CONTRAVE Savings benefits, your prescription will be processed with the assumption that you are a cash-paying customer. For Medicare Part D patients, the cash payments you make for CONTRAVE will not count towards your true out-of-pocket expenses. If Medicare or TRICARE coverage status for CONTRAVE changes in the future, your CONTRAVE Savings benefits may change too.

Additionally, the CONTRAVE Savings Card cannot be used if you are purchasing your prescription through the Get CONTRAVE Now online consult and home delivery service.

To learn more about eligibility, visit the Save page.

Yes, you will get a similar discount whether you pick up your prescription at the pharmacy, or receive it through the mail. You will receive a similar discount whether your mailed prescription is for one month or three months.

You don’t need a replacement card if your pharmacy already has your information on file. Call your pharmacy to check. If they don’t have your information, then call 1-800-905-5576 for assistance.

If you still have your card on hand, you can give your new pharmacy the same card ID number. If you’ve lost the card, call a customer service representative at 1-800-905-5576 for assistance. If you’re switching to another pharmacy within the same chain, your information should still be in the system.

Orexigen Therapeutics, Inc., the company that brings you CONTRAVE, respects your right to have personal and medical information kept confidential. Only Orexigen and its third-party partners will use your information. Orexigen Therapeutics and companies providing services to Orexigen Therapeutics will not sell or rent your personally identifiable information, as described in the Privacy Policy.

About the Online Doctor Consult

Setting up an online consultation is simple. First, select your state to find a “Get CONTRAVE Now” online service option available in your area. You will be directed to a consult site offered by one of our partners where you can set up an account and your medical profile. Your profile will be reviewed, and you will be notified if you are a good potential candidate for a CONTRAVE prescription. You will then be asked to participate in a video or telephone consultation with a doctor. Only a doctor can determine if CONTRAVE is right for you.

The “Get CONTRAVE Now” online service and participating healthcare professionals are independent and not employees or contractors of Orexigen Therapeutics.

Watch this brief video to learn more

Most states offer two ways to consult with a physician about CONTRAVE online. In one option, a nurse will guide you. In the other, you navigate the process on your own. If you choose to have a nurse guide you, a registered nurse will call and help you create your medical profile before you speak with a physician. Shortly after your CONTRAVE prescription is written, the nurse will call to check in with you and answer any questions you may have. With this option, you will need to set up a separate account with our partner, Ridgeway Mail Order Pharmacy, for your free home delivery service.

If you choose the “Navigate on your own” option, you will participate in an online consultation (via phone or video) with just a physician–no other healthcare professionals will be involved. Also with this option, you won’t need to create another account for home delivery but local pharmacy pick up will not be an option.

This consult fee is a one-time payment for your online doctor visit, which is similar to the standard fee (or co-pay) you would incur for an in-person doctor visit. You should check with your insurance provider to determine if the consult fee can be reimbursed by your specific plan. The consultation fee for both the “Nurse will guide you” and the “Navigate on your own” service is $65. Choosing the online consultation may make the process of getting started on CONTRAVE easier or more convenient.

Patients who use the “Get CONTRAVE Now” service receive a discount at the retail pharmacy price, even without using the CONTRAVE savings card.  The cost is $99 per month with free standard shipping.

If you have questions about Contrave, one or more of the following may direct you:
● If you have a medical emergency, CALL 911.
● For specific concerns about CONTRAVE, speak directly with your local doctor.
● For general questions about CONTRAVE call 1- 800-905-5576.

Stop taking CONTRAVE and call a healthcare provider right away if you have any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempts to commit suicide; depression; anxiety; feeling agitated or restless; panic attacks; trouble sleeping (insomnia); irritability; aggression, anger, or violence; acting on dangerous impulses; an extreme increase in activity and talking (mania); other unusual changes in behavior or mood.

Obesity medications are often not covered by insurance providers. Please check with your insurance provider beforehand if you are unsure. Without insurance coverage for prescription obesity medications, you will pay only $99 per month for CONTRAVE through the “Get Contrave Now” service.

If you consult an online doctor through the “Nurse will guide you” option, local pharmacy pick-up is possible. If you would prefer to pick up your prescription at your local pharmacy, please let your physician know at the time of your online consult. The physician may ask you information such as the pharmacy’s name, address, and phone number.

Local pharmacy pick-up is not available with the “Navigate on your own” service.

ABOUT Home Delivery

Once you sign up, our home delivery partner, Ridgeway Mail Order Pharmacy, will deliver your CONTRAVE prescription straight to your door. If you already have a CONTRAVE prescription at a local pharmacy, Ridgeway Mail Order Pharmacy will transfer it for you. You can create an account here or call 1-800-630-3214 to sign up for home delivery.

If you participate in the “Get CONTRAVE Now” online consultation service with nurse assistance, you will receive an email with instructions on how to sign up for the home delivery service after your online weight loss doctor consult. If you need more information, simply call 1-800-630-3214 any time after your consult.

Currently, the CONTRAVE savings card cannot be used with the online consultation or free home delivery option. But your monthly CONTRAVE prescription should cost just about the same amount whether you use the online consultation and home delivery service or use your CONTRAVE savings card at a local pharmacy.

Yes, you can transfer other prescriptions. Once you have signed up for the home delivery service, please contact Ridgeway Mail Order Pharmacy by calling 1-800-630-3214. Please note: While your CONTRAVE prescription comes with free, standard USPS first-class shipping, other prescriptions may be subject to insurance costs, shipping rates, and additional fees.

Yes. Call our free home delivery service partner, Ridgeway Mail Order Pharmacy at 1-800-630-3214. They will create your account and complete the prescription transfer for you. Please note: if you have insurance that may cover Contrave, you could pay less than $99. Ridgeway Mail Order Pharmacy can help you determine your final price.

To get started, call our home delivery partner, Ridgeway Mail Order Pharmacy, at 1-800-630-3214. After setting up your account, they will connect with your doctor so that you can have your CONTRAVE prescription delivered to your home for free.  Download instructions.


We regret to inform you that ScaleDown will stop providing service as of July 31, 2017.  At that time, your scale will no longer transmit to us and you will no longer receive daily feedback or weekly emails. The scale is yours to keep. If your membership expires prior to July 31, you will not be able to renew.

You may call one of our customer service representatives at 800-905-5576 for more information or contact ScaleDown™ directly at or visit ScaleDown, LLC, is an independent company and not part of Orexigen Therapeutics, Inc.

You may call one of our customer service representatives at 800-905-5576 for more information or contact ScaleDown™ directly at or visit ScaleDown, LLC, is an independent company and not part of Orexigen Therapeutics, Inc.

No, the smart scale is yours to keep as you continue to track your weight-loss progress.

You may call one of our customer service representatives at 800-905-5576 for more information or contact ScaleDown™ directly at or visit ScaleDown, LLC, is an independent company and not part of Orexigen Therapeutics, Inc.