Get answers to your most frequently asked questions about CONTRAVE.

We want to answer your questions and support you on your weight-loss journey. Visit our Medication Guide for more information about CONTRAVE, or call one of our customer service representatives at 1-800-905-5576. You’ll also find answers to the most commonly asked questions below.


About CONTRAVE

CONTRAVE is an FDA-approved, prescription-only weight-loss medicine that may help adults who are overweight or struggle with obesity lose weight and keep it off. CONTRAVE should be used along with diet and exercise.

CONTRAVE contains two well-known FDA-approved drugs, naltrexone and bupropion that, individually, have been on the market for over 20 years. Naltrexone is an anti-addiction medication approved to treat alcohol and opioid dependence. Bupropion is an antidepressant approved to treat depression and seasonal affective disorder and is an aid to smoking cessation treatment. (These individual drugs are not approved for weight loss and CONTRAVE is not indicated for the treatment of depression, smoking cessation, or alcohol or opioid dependence.)

The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood.

CONTRAVE is believed to work on two areas of the brain—the hypothalamus to help reduce hunger and the mesolimbic reward system to help control cravings—that can get in the way of weight loss.

Across three one-year studies, nearly half of CONTRAVE patients lost 5% or more of their body weight and kept it off versus 23% of patients on placebo.

CONTRAVE is approved for use in adults with a body mass index (BMI) of 30 or greater (obese) or 27 or greater (overweight) who have at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol. It is to be used along with a reduced-calorie diet and increased physical activity.

CONTRAVE is not for everyone. Do not take CONTRAVE if you:

  • Have a seizure disorder
  • Are pregnant or trying to get pregnant
  • Have an eating disorder such as anorexia or bulimia
  • Are under the age of 18
  • Have uncontrolled hypertension
  • Use other medicines that contain bupropion such as Wellbutrin and Aplenzin
  • Are dependent on opioid medicines or use medicines to help stop taking opioids, such as methadone or buprenorphine or are in opiate withdrawal
  • Drink a lot of alcohol and abruptly stop drinking
  • Use medicines called sedatives like benzodiazepines, or anti-seizure medicines, and you stop using them suddenly
  • Are allergic to any of the ingredients in CONTRAVE, such as naltrexone HCI and bupropion HCI
  • Are taking medicines called monoamine oxidase inhibitors (MAOIs)

See the Medication Guide to learn more.

CONTRAVE should be taken by mouth in the morning and in the evening and should not be taken with high-fat meals.

CONTRAVE dosing should be increased slowly according to the following schedule:

Morning Dose Evening Dose
Week 1 1 tablet none
Week 2 1 tablet 1 tablet
Week 3 2 tablets 1 tablet
Week 4 – onward 2 tablets 2 tablets

A total daily dosage of two CONTRAVE tablets should be reached at the start of week four.

It’s important to take CONTRAVE exactly as your doctor prescribes it. Keep in mind that some people, like those with renal or hepatic impairment, or those taking other medications, may need to follow a different dosing schedule.

To learn more about dosing, see the Medication Guide.

The most common side effects reported with CONTRAVE include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.

If you experience any of the following, stop taking CONTRAVE and tell your healthcare provider right away:

 

  • Suicidal thoughts or actions
  • Seizures
  • Increases in blood pressure or heart rate
  • Liver damage or hepatitis (symptoms include stomach area pain lasting more than a few days, dark urine, yellowing of the whites of your eyes, or tiredness)
  • Manic episodes
  • Visual problems (symptoms include eye pain, changes in vision, swelling or redness in or around the eye)
  • Increased risk of low blood sugar (hypoglycemia) in people with type 2 diabetes mellitus who also take medicines to treat their diabetes (such as insulin or sulfonylureas)
  • Severe allergic reaction (signs and symptoms include rash, itching, hives, fever, swollen lymph glands, painful sores in your mouth or around your eyes, swelling of your lips or tongue, chest pain, or trouble breathing)

See the Full Prescribing Information or the Medication Guide to learn more about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088.

About the CONTRAVE Savings Card

We no longer feature the login and account sections on the new Contrave.com website. To help simplify your CONTRAVE experience, we now allow users to sign up for the Savings Card without a password.  If you have questions about your account, please reach out to our customer service representatives at 1-800-905-5576 and they will be happy to assist you.

Once you sign up for the CONTRAVE Savings Card, you will be able to upload it right away online. Print it or take a picture of it on your smartphone and bring it with you the first time you fill your prescription. Once you use your Savings Card at the pharmacy, you do not need to bring it again. The pharmacy will keep your card information on file.

If you have private health insurance with prescription coverage, you may pay no more than $1 a day for CONTRAVE. If you don’t have prescription coverage, you may pay no more than $3 a day. Tell your pharmacist what kind of health insurance you have so you can pay the lowest copay possible.

You can register for the CONTRAVE Savings Card here. If you are having trouble signing up online, you can call 1-800-905-5576 for assistance.

The CONTRAVE Savings Card cannot be used if you are currently a Medicaid Beneficiary. Medicare Part D, and TRICARE beneficiaries are eligible for CONTRAVE Savings. However, to receive the CONTRAVE Savings benefits, your prescription will be processed with the assumption that you are a cash-paying customer. For Medicare Part D patients, the cash payments you make for CONTRAVE will not count towards your true out-of-pocket expenses. If Medicare or TRICARE coverage status for CONTRAVE changes in the future, your CONTRAVE Savings benefits may change too.

Additionally, the CONTRAVE Savings Card cannot be used if you are purchasing your prescription through the Get CONTRAVE Now online consult and home delivery service.

To learn more about eligibility, visit the Save page.

Yes, you will get a similar discount whether you pick up your prescription at the pharmacy, or receive it through the mail. You will receive a similar discount whether your mailed prescription is for one month or three months.

You don’t need a replacement card if your pharmacy already has your information on file. Call your pharmacy to check. If they don’t have your information, then call 1-800-905-5576 for assistance.

If you still have your card on hand, you can give your new pharmacy the same card ID number. If you’ve lost the card, call a customer service representative at 1-800-905-5576 for assistance. If you’re switching to another pharmacy within the same chain, your information should still be in the system.

Orexigen Therapeutics, Inc., the company that brings you CONTRAVE, respects your right to have personal and medical information kept confidential. Only Orexigen and its third-party partners will use your information. Orexigen Therapeutics and companies providing services to Orexigen Therapeutics will not sell or rent your personally identifiable information, as described in the Privacy Policy.

About the Live Doctor Consult

It starts when you set up an account on getcontravenow.com and complete an online medical assessment. After the online physician reviews that assessment and determines that you might be eligible for CONTRAVE, you’ll be invited to participate in a video consultation with a physician. If you receive a prescription, payment will be collected and your prescription will be shipped to you directly. Please note that Get CONTRAVE Now is not owned or operated by Orexigen Therapeutics.

You will be notified during the consult, your order will be cancelled, and your credit card will not be charged.

If you have questions about CONTRAVE or would like guidance regarding management of side effects, please contact your local physician or hospital for care.

About CONTRAVE Support and the ScaleDownTM Program

We no longer feature the login and account sections on the new Contrave.com website. To help simplify your CONTRAVE experience, we now allow users to sign up for the ScaleDown™ program without a password.  If you have questions about your account, please reach out to our customer service representatives at 1-800-905-5576 and they will be happy to assist you.

For a limited time, yes. The makers of CONTRAVE are pleased to assist you on your weight loss journey with a special offering of the ScaleDownTM program. This includes a complimentary 3-month subscription to the weight management program and a smart scale.

You may be eligible for the ScaleDownTM program benefits if you are a new patient on CONTRAVE. Sign up for weight-loss support on contrave.com/connect to initiate the process to determine if you are eligible. Please note that patients who purchase their prescription through Get CONTRAVE Now are not currently eligible.

Get started by signing up for weight-loss support on contrave.com/connect. Then you will receive an email after your initial registration is verified. After you’ve filled your CONTRAVE prescription, you will be provided further instructions on how to complete the registration process. Use the link provided to you and answer just a few more questions; then you’ll be on your way and should receive your scale in approximately 10 to 12 business days.

Call one of our customer service representatives at 1-800-905-5576 to learn more about this offering for new patients on CONTRAVE.

To learn more about ScaleDownTM , visit www.scaledown.me. ScaleDown, LLC, is an independent company and not part of Orexigen Therapeutics, Inc.