The Science Behind Your Weight-Loss Struggles

If you’re struggling to lose weight, you’re not alone. 9 out of 10 people who don’t achieve their weight-loss goals struggle with hunger and cravings. And it’s not due to lack of willpower or commitment, but rather it could be your brain sending hunger or craving signals that are working against you.

*Other areas of the brain may be involved.

See The Brain’s Role In Creating Hunger and Cravings

Through science we can better understand the role of the brain when it comes to weight loss. There are two areas in your brain that are scientifically proven to control hunger and cravings.* Weight-loss struggles can happen when they send signals for you to crave unhealthy foods or feel hungry even when you have already eaten. Watch the video to learn more.

The hunger center (hypothalamus) can reduce hunger, telling you to eat again or eat more

The mesolimbic circuit or reward system can create cravings that seem uncontrollable even when you’re not hungry

With reduced hunger and controlled cravings, weight loss can happen.

If you have found that—regardless of your commitment—your attempts with diet and exercise programs are just not working on their own, it might be time to talk with your doctor about adding a prescription weight-loss medication that addresses your weight loss struggles.

Meet FDA-Approved CONTRAVE And Learn About The Science Behind It

CONTRAVE works in 2 key areas of the brain to reduce hunger and control cravings—2 main issues that contribute to weight gain. When added to a diet and exercise program, CONTRAVE has been shown to help people lose weight and keep it off. Watch the video to learn more.

The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood.
The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood.

The hypothalamus (hunger center) to help reduce hunger

The mesolimbic reward system to help control cravings

With CONTRAVE, Weight Loss Can Happen

Adding CONTRAVE to a diet and exercise plan has helped thousands of people lose weight and keep it off.

Across 3 studies, patients who were overweight or struggling with obesity lost approximately 2-4x more weight over 1 year by adding CONTRAVE than with diet and exercise alone

Nearly half of patients taking CONTRAVE lost 5% or more body weight and kept it off (vs 23% of patients taking placebo). Individual results may vary.

According to 3 multicenter, double-blind, placebo-controlled obesity trials (BMI ≥30 kg/m2, or BMI ≥27 kg/m2 with at least 1 comorbidity of hypertension, dyslipidemia, or type 2 diabetes) conducted to evaluate the effect of CONTRAVE in conjunction with reduced caloric intake and increased physical activity, the average percentage of weight loss in patients at 56 weeks ranged from 3.7% to 8.1% with CONTRAVE, compared to 1.3% to 4.9% with placebo. The percentage of patients who achieved a clinically meaningful treatment response (defined as achieving at least 5% weight loss after 1 year of treatment) ranged from 36% to 57% with CONTRAVE compared to 17% to 43% with placebo.

Ready To Start Your Weight-Loss Journey With CONTRAVE?

Click below to talk with doctor online and learn if CONTRAVE is right for you.

Or if you would rather speak with your own doctor, use our personalized doctor discussion guide to help you prepare for the conversation.