When you’re trying to lose weight, your brain could be working against you. Find out how CONTRAVE may help.

The Science Behind CONTRAVE

FDA-approved, prescription-only CONTRAVE contains two medicines, bupropion and naltrexone. These well-known drugs have been prescribed separately for years—bupropion for depression and smoking cessation, and naltrexone for alcohol and opioid dependence.1 CONTRAVE combines these medicines and is believed to work on two areas of your brain—the hunger center and the reward system—to reduce hunger and help control cravings.2-3

1The individual components of CONTRAVE are not approved for weight loss. CONTRAVE is not approved to treat depression or other mental illnesses, alcohol or opioid dependency, or to help people quit smoking.
2Other areas of the brain may be involved in weight loss.
3The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood.
4Across three 56-week studies, 46% of patients on CONTRAVE lost 5% or more body weight (vs 23% of patients on placebo). Results may vary.

CONTRAVE has a well-studied safety and tolerability profile and has minimal risk of abuse or dependence. Three one-year studies have shown that patients who take CONTRAVE lose approximately 2 to 4 times more weight than with diet and exercise alone.4 In addition, patients in one study, who also participated in an intensive diet and exercise program and remained on CONTRAVE for a full year, lost 25 pounds on average.

In one study, CONTRAVE users who took the medicine for a full year:

Lost

4x

more weight than with diet and exercise alone4

In another study, patients who stayed on CONTRAVE for a full year and participated in intensive behavior modification:

Lost

25lbs

on average
1The individual components of CONTRAVE are not approved for weight loss. CONTRAVE is not approved to treat depression or other mental illnesses, alcohol or opioid dependency, or to help people quit smoking.
2Other areas of the brain may be involved in weight loss.
3The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood.
4Across three 56-week studies, 46% of patients on CONTRAVE lost 5% or more body weight (vs 23% of patients on placebo). Results may vary.

Learn more about the potential for long-term weight loss with CONTRAVE

CONTRAVE was studied for efficacy and safety in numerous clinical trials that included thousands of patients.

In three long-term studies, 2,322 participants were enrolled who were struggling with obesity (BMI of 30 or greater) or overweight (BMI of 27 or greater).  Those with a BMI between 27 and 29.9 had at least one weight-related medical condition, such as controlled hypertension, dyslipidemia, or diabetes.

While some participants received CONTRAVE, others were randomly selected to receive a placebo. Everyone participated in lifestyle modification programs that included a reduced-calorie diet and regular physical activity.

After 56 weeks, across the three studies, 46% of CONTRAVE patients lost 5% or more of their body weight and kept if off with CONTRAVE versus 23% of patients on placebo.

Study 1

In this 56-week study, the CONTRAVE group lost 5.4% of their body weight (on average) compared with the placebo group who lost 1.3% (on average) with diet and exercise alone.

Additionally, 42% of the CONTRAVE users lost at least 5% of their total body weight (while 17% of the placebo group lost at least 5% of their total body weight with diet and exercise).

For participants who remained on CONTRAVE for the whole study, average weight loss was 8.1% or approximately 18 pounds, which was 4 times more weight than participants taking placebo.

COR-1 study

Study 2

In this 56-week study, patients participated in an intensive diet and exercise program, including group visits. At 56 weeks, the CONTRAVE users lost 8.1% (on average) of their total body weight compared with a body weight loss of 4.9% (on average) for the placebo group.

Additionally, 57% of those who took CONTRAVE lost at least 5% of their total body weight (while 43% of those on placebo lost at least 5% body weight with diet and exercise alone).

For participants who remained on CONTRAVE for the whole study, average weight loss was 11.5% or approximately 25 pounds.

COR-BMOD study

Study 3

For people with type 2 diabetes, CONTRAVE has the potential to provide sustainable weight loss and this weight loss may also lower A1C levels. In this study, the CONTRAVE group lost 3.7% of their body weight (on average) compared with the placebo group who lost 1.7% (on average) with diet and exercise alone after 56 weeks.

Additionally, 36% of the CONTRAVE users lost at least 5% of their total body weight (while 18% of the placebo group lost at least 5% of their total body weight with diet and exercise).

CONTRAVE users also had a reduction in HbA1c of 0.6% (compared with a reduction of 0.1% in the placebo group) at 56 weeks. (Keep in mind that CONTRAVE is not approved to treat diabetes.)

COR-Diabetes study

Taking CONTRAVE

If you’re new to CONTRAVE, it’s important to start by slowly increasing your dose over time to help you adjust to treatment. Begin with one morning tablet during your first week, and then gradually work up to two tablets twice a day by week four.   Remember to always take CONTRAVE exactly as your doctor prescribes. Refer to the CONTRAVE dosing chart on the next tab to help you stay on track, and know that some people, like those with renal or hepatic impairment, or those taking other medications, may need to follow a different dosing schedule.

Some people may experience nausea as they increase their dose of CONTRAVE. For most people, this symptom goes away within the first four weeks of starting CONTRAVE. Other common CONTRAVE side effects include constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea. Call your doctor if you experience common side effects while taking CONTRAVE that bother you or don’t go away. Learn more in the Medication Guide.

It’s important to avoid taking CONTRAVE if you:

  • Have or have had a seizure disorder
  • Have a mood disorder or certain kinds of mental illness
  • Have uncontrolled hypertension
  • Are pregnant or trying to get pregnant
  • Have an eating disorder

Also, be careful not to take CONTRAVE with high-fat meals, and also avoid drinking a lot of alcohol.

Be sure to tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. This is important because CONTRAVE may affect the way other medications work, especially opioid medicines or medicines to help stop taking opioids, such as methadone or buprenorphine, sedatives, benzodiazepines, and monoamine oxidase inhibitors.

If you have not lost at least 5% of your weight after 16 weeks of taking CONTRAVE, your healthcare provider might tell you to stop taking it. CONTRAVE does not work for everyone in the same way.

Please see Full Prescribing Information or the Medication Guide for more details about CONTRAVE.

Talk to Your Doctor

Sharing important information with your doctor about your previous attempts to lose weight and how you may have struggled to control hunger and cravings will help you get the most from your visit. Create and download this personal discussion guide to help you start the conversation about weight loss, and ask your doctor if CONTRAVE is right for you.

Create your personal Doctor Discussion Guide

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